STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lim3Lim3, isoform G; Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity. (555 aa)    
Predicted Functional Partners:
tup
Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development.
   
 
0.957
Chi
Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance.
    
 
 0.859
HGTX
GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation.
   
 
 0.714
exex
Extra-extra (exex) encodes a homeodomain transcription factor that is expressed in and regulates the differentiation of motor neurons that project axons to ventral body wall muscles. Within the central nervous system, the product of exex negatively interacts with the products of Lim3 and eve to govern neuronal specification and differentiation. The roles of the product of exex include neuronal specification and differentiation.
   
 
 0.705
Ssdp
Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes.
    
 
 0.687
side-VII
Sidestep VII, isoform A.
      
 0.670
beat-Vb
Beaten path Vb, isoform A; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules.
      
 0.667
side-VIII
Sidestep VIII, isoform B.
      
 0.628
side-VI
Sidestep VI, isoform B.
      
 0.626
side-IV
Sidestep IV, isoform C.
      
 0.625
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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