STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
beat-IIIbBeaten path IIIb, isoform D; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (404 aa)    
Predicted Functional Partners:
CG7966
Uncharacterized protein; Selenium binding.
      
 0.797
hwt
Heavyweight, isoform A; Phosphotyrosine residue binding. It is involved in the biological process described with: regulation of establishment of planar polarity.
   
  
 0.702
NimB3
GEO11169p1; It is involved in the biological process described with: defense response to bacterium.
      
 0.669
Gyc88E
Soluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
   
    0.620
beat-Va
Beaten path Va, isoform A; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor neuron axon guidance.
   
 
0.514
Arpc2
Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
      
 0.497
CG7560
GH04035p; FAD binding; methylenetetrahydrofolate reductase (NAD(P)H) activity. It is involved in the biological process described with: methionine biosynthetic process; tetrahydrofolate interconversion; one-carbon metabolic process; oxidation-reduction process.
      
 0.491
Fife
Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior.
   
   0.488
Arp2
Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
    
 
 0.467
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
   
 
 0.433
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.