STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bibNeurogenic protein big brain; Essential for proper differentiation of ectoderm. Acts synergistically with neurogenic locus proteins Notch and Delta during the separation of neural and epidermal cell lineages in response to the lateral inhibition signal. Voltage-insensitive monovalent cation channel. Ion transport is blocked by the presence of divalent cations. Belongs to the MIP/aquaporin (TC 1.A.8) family. (737 aa)    
Predicted Functional Partners:
AQP
Aquaporin; Channel activity; Belongs to the MIP/aquaporin (TC 1.A.8) family.
     
 0.956
Eglp1
Entomoglyceroporin 1; Water channel activity; channel activity. It is involved in the biological process described with: transmembrane transport; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
 0.949
amx
TM2 domain-containing protein almondex; Involved in the control of cell fates in the neurectoderm. Acts as a positive regulator of Notch pathway and is required at different levels during development; Belongs to the TM2 family.
      
 0.679
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
   
 
 0.665
Eglp2
Entomoglyceroporin 2, isoform C; Water channel activity; channel activity. It is involved in the biological process described with: transmembrane transport; renal system process; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
0.605
l(2)gd1
Coiled-coil and C2 domain-containing protein 1-like; Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling; Belongs to the CC2D1 family.
      
 0.600
Gpo2
Glycerol-3-phosphate dehydrogenase (quinone) activity; calcium ion binding. It is involved in the biological process described with: glycerol metabolic process; glycerol-3-phosphate metabolic process; oxidation-reduction process; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
  
  
 0.595
Gpo1
Glycerol-3-phosphate dehydrogenase; Glycerophosphate oxidase 1 (Gpo1) encodes a mitochondrial inner membrane protein with glycerol-3-phosphate dehydrogenase activity; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
  
  
 0.595
Gpo3
Glycerol-3-phosphate dehydrogenase (quinone) activity. It is involved in the biological process described with: oxidation-reduction process; glycerol-3-phosphate metabolic process; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
  
  
 0.595
neur
Neuralized (neur) encodes an E3 ubiquitin ligase of the RING family. It is part of the Notch signaling pathway, where it is thought to contribute to the endocytosis-dependent activation of the ligand. It also has Notch-independent functions in epithelial morphogenesis.
   
  
 0.587
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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