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HtrA2 protein (fruit fly) - STRING interaction network
"HtrA2" - Serine protease HTRA2, mitochondrial in Drosophila melanogaster
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HtrA2Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (422 aa)    
Predicted Functional Partners:
Pink1
PTEN-induced putative kinase 1, isoform A; Protein kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity (721 aa)
     
 
  0.970
park
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily (482 aa)
       
 
  0.932
rho-7
Rhomboid-7, isoform A; Rhomboid-7 (Rho-7) is an intramembrane serine protease of the rhomboid family present in the inner membrane of mitochondria. It regulates mitochondrial fusion during spermatogenesis and muscle development. Rho-7 genetically interacts with fog, Opa1 and Pink1, which is also a substrate of Rho-7 (351 aa)
   
 
  0.913
Diap1
Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress [...] (438 aa)
       
 
  0.902
EndoG
Endonuclease G; Endoribonuclease activity; metal ion binding; endodeoxyribonuclease activity; nucleic acid binding. It is involved in the biological process described with- mitochondrion inheritance; spermatid development; DNA-dependent DNA replication; ectopic germ cell programmed cell death (310 aa)
     
   
  0.877
Trap1
Trap1, isoform A; Trap1 is a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction (691 aa)
     
   
  0.871
DJ-1alpha
Protein DJ-1alpha; Involved in protection against reactive oxygen species (ROS) (By similarity). Does not play a role in methylglyoxal detoxification (By similarity) (217 aa)
     
   
  0.870
dj-1beta
Protein dj-1beta; Involved in protection against reactive oxygen species (ROS) (By similarity). Does not play a role in methylglyoxal detoxification (205 aa)
     
   
  0.870
dbo
Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth (623 aa)
           
  0.858
AIF
Putative apoptosis-inducing factor 1, mitochondrial; Probable NADH oxidoreductase (By similarity). Mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function; Belongs to the FAD-dependent oxidoreductase family (739 aa)
     
 
  0.849
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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