| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aprt | CG11811 | FBpp0312099 | FBpp0075994 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | 0.967 |
| Aprt | CG5276 | FBpp0312099 | FBpp0081866 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CG5276 protein; Nucleoside-diphosphatase activity; guanosine-diphosphatase activity; calcium ion binding; nucleoside-triphosphatase activity; uridine-diphosphatase activity. It is involved in the biological process described with: proteoglycan biosynthetic process. | 0.911 |
| Aprt | CG8891 | FBpp0312099 | FBpp0078684 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.944 |
| Aprt | NTPase | FBpp0312099 | FBpp0304733 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | NTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family. | 0.908 |
| Aprt | Pde6 | FBpp0312099 | FBpp0303081 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells. | 0.902 |
| Aprt | PrBP | FBpp0312099 | FBpp0079352 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta; 3',5'-cyclic-nucleotide phosphodiesterase activity; protein binding. It is involved in the biological process described with: mushroom body development; sensory perception of light stimulus. | 0.903 |
| Aprt | bur | FBpp0312099 | FBpp0310411 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. | 0.993 |
| CG11811 | Aprt | FBpp0075994 | FBpp0312099 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.967 |
| CG11811 | CG5276 | FBpp0075994 | FBpp0081866 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | CG5276 protein; Nucleoside-diphosphatase activity; guanosine-diphosphatase activity; calcium ion binding; nucleoside-triphosphatase activity; uridine-diphosphatase activity. It is involved in the biological process described with: proteoglycan biosynthetic process. | 0.900 |
| CG11811 | CG8891 | FBpp0075994 | FBpp0078684 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.954 |
| CG11811 | NTPase | FBpp0075994 | FBpp0304733 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | NTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family. | 0.900 |
| CG11811 | Pde6 | FBpp0075994 | FBpp0303081 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells. | 0.906 |
| CG11811 | PrBP | FBpp0075994 | FBpp0079352 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta; 3',5'-cyclic-nucleotide phosphodiesterase activity; protein binding. It is involved in the biological process described with: mushroom body development; sensory perception of light stimulus. | 0.905 |
| CG11811 | bur | FBpp0075994 | FBpp0310411 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. | Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. | 0.958 |
| CG31183 | CG8891 | FBpp0311979 | FBpp0078684 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
| CG31183 | Pde6 | FBpp0311979 | FBpp0303081 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. | cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells. | 0.715 |
| CG31183 | PrBP | FBpp0311979 | FBpp0079352 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. | Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta; 3',5'-cyclic-nucleotide phosphodiesterase activity; protein binding. It is involved in the biological process described with: mushroom body development; sensory perception of light stimulus. | 0.677 |
| CG42637 | CG8891 | FBpp0291485 | FBpp0078684 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
| CG42637 | Pde6 | FBpp0291485 | FBpp0303081 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] | cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells. | 0.781 |
| CG42637 | PrBP | FBpp0291485 | FBpp0079352 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] | Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta; 3',5'-cyclic-nucleotide phosphodiesterase activity; protein binding. It is involved in the biological process described with: mushroom body development; sensory perception of light stimulus. | 0.660 |