STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vvlPOU domain protein CF1A; Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system. Belongs to the POU transcription factor family. Class-3 subfamily. (742 aa)    
Predicted Functional Partners:
D
Dichaete (D) encodes an HMG-domain protein and member of the Sox family of transcription factors. Its roles include hindgut development, embryonic segmentation, and nervous system development.
   
 
 0.857
FMRFaR
FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family.
      
 0.792
acj6
Inhibitory POU protein; Modulates gene transcription; simultaneously generates both a specific activator and an inhibitor of gene transcription, capable of modulating two distinct regulatory programs during neural development. Has a role in olfactory behavior; Belongs to the POU transcription factor family. Class-4 subfamily.
   
 
0.764
tgo
Aryl hydrocarbon receptor nuclear translocator homolog; Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation.
    
 
 0.731
Gug
Grunge, isoform J; Grunge (Gug) encodes a nuclear repressor protein that likely responds to Egfr signaling to control cell behavior for normal developmental patterning.
   
 
 0.695
trh
Protein trachealess; Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles. It may induce a general fate of branched tubular structures of epithelial origin. Functions with tgo to regulate expression of btl.
   
 
 0.681
salm
Homeotic protein spalt-major; Spalt major (salm) encodes a zinc finger transcriptional repressor. It mediates most dpp functions during development of the central part of the wing through regulation of the products of kni and ara. The product of salm is required for cell specification during the development of the nervous system, muscle, eye or trachea.
   
 
 0.675
Pcf11
Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation.
      
 0.661
salr
Spalt-related, isoform A; Spalt-related (salr) encodes a zinc finger transcriptional repressor that, together with the product of salm, mediates most dpp functions during development of the central part of the wing. It is repressed by the product of Ubx during haltere development.
   
 
 0.639
CG13884
Uncharacterized protein.
      
 0.610
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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