STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Flo2Flotillin-2; Flotillin 2 (Flo2) encodes encodes a scaffold protein that contributes to the anti-parasitoid immune response and the secretion and spreading of the ligands encoded by wg and hh; Belongs to the band 7/mec-2 family. Flotillin subfamily. (448 aa)    
Predicted Functional Partners:
Flo1
Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
  
0.907
kek5
Kekkon 5 (kek5) encodes a transmembrane protein involved in BMP signaling regulation.
   
 
 0.701
Phb2
Prohibitin.
   
  
 0.693
CG32591
FI08446p.
      
 0.669
Faf2
Fas-associated factor 2 (Faf2) encodes a putative ubiquitin ligase with a proteosome dependent function.
   
 
 0.628
CG14406
Uncharacterized protein, isoform A.
      
 0.607
TSG101
Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles.
      
 0.605
Syb
Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release.
   
 0.515
Rho1
Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...]
   
  0.503
CG9503
CG9503-PA; Oxidoreductase activity; oxidoreductase activity, acting on CH-OH group of donors; flavin adenine dinucleotide binding. It is involved in the biological process described with: oxidation-reduction process; ecdysteroid metabolic process.
      
 0.493
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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