STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Inx3Innexin 3 (Inx3) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the product of Inx2. Loss of Inx3 leads to the destabilization of the products of ogre, Inx2 and shg at the plasma membrane, suggesting that these four proteins form a complex. (395 aa)    
Predicted Functional Partners:
ogre
Innexin inx1; Optic ganglion reduced (ogre) encodes one of the innexin subunits spanning the membrane 4 times. Together with the products of Inx2 and Inx3, it forms homo or hetero oligomers forming gap junctions, which allow the transfer of small solute between cells.
  
  
0.777
Inx2
Innexin inx2; Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst f [...]
  
 
0.742
link
LD15563p.
   
  
 0.740
KP78b
KP78b, isoform A; ATP binding; tau-protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; microtubule cytoskeleton organization; intracellular signal transduction.
   
  
 0.730
CG8960
GEO04221p1.
   
  
 0.727
CG1647
Uncharacterized protein, isoform A; Zinc ion binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
   
 
 0.663
CG4440
GEO09613p1.
   
  
 0.650
Tom
Twin of m4 (Tom) is a member of the Bearded gene family that encodes a regulator of the Notch signaling pathway.
   
    0.626
Ilp4
Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family.
   
    0.626
sala
Protein spalt-accessory; Likely to be involved in the establishment of the head.
   
    0.623
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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