STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ack-likeActivated Cdc42 kinase-like (Ack-like) encodes a non-receptor tyrosine kinase that participates in signaling by the small GTPase encoded by Cdc42. It is involved in embryonic dorsal closure, an epithelial morphogenetic event. (1495 aa)    
Predicted Functional Partners:
drk
Protein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory).
    
 
 0.683
mRpS31
Mitochondrial ribosomal protein S31; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
      
 0.658
POSH
Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway.
   
 
 0.540
Teh2
TipE homolog 2, isoform B; tipE homolog 2 (Teh2) encodes a protein involved in regulation of sodium transport.
      
 0.525
Ns2
Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
      
 0.491
pxb
Pxb (pxb) encodes a protein involved in response to ethanol, long-term memory and regulation of hemocyte proliferation.
      
 0.489
Teh1
TipE homolog 1, isoform B; tipE homolog 1 (Teh1) encodes a protein involved in regulation of sodium transport.
      
 0.459
Chc
Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles.
    
 
 0.442
TH1
Negative elongation factor D; TH1 (TH1) encodes one of four subunits that constitutes the NELF complex. The NELF complex along with DSIF causes RNA polymerase II to pause 20 to 50 nucleotides downstream from the transcription start site of most and possibly all actively transcribed genes in a process commonly called promoter proximal pausing.
      
 0.433
Rbm13
Protein MAK16 homolog; It is involved in the biological process described with: maturation of LSU-rRNA; maturation of 5.8S rRNA; Belongs to the MAK16 family.
      
 0.420
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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