STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSRBifunctional arginine demethylase and lysyl-hydroxylase PSR; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. (441 aa)    
Predicted Functional Partners:
JMJD5
Jumonji domain containing 5, isoform B; 2-oxoglutarate-dependent dioxygenase activity; chromatin binding; histone demethylase activity (H3-K36 specific). It is involved in the biological process described with: G2/M transition of mitotic cell cycle; histone H3-K36 demethylation.
      
 0.595
tbrd-3
Testis-specifically expressed bromodomain containing protein-3 (tbrd-3) encodes a protein that interacts with the products of tbrd-1, tbrd-2 and testis-specific TAFs.
    
 
 0.547
tbrd-2
Testis-specifically expressed bromodomain containing protein-2 (tbrd-2) encodes a protein required for male fertility. It interacts with the products of tbrd-1, tbrd-3 and testis-specific TAFs.
    
 
 0.547
fs(1)h
Homeotic protein female sterile; Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx.
    
 
 0.547
tbrd-1
Testis-specifically expressed bromodomain containing protein-1 (tbrd-1) encodes a protein involved in gene activation that is required for male germ cell differentiation. It interacts with the products of tbrd-2, tbrd-3 and testis-specific TAFs.
    
 
 0.547
JHDM2
JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure.
      
 0.536
lid
Lysine-specific demethylase lid; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.
      
 0.527
CG13609
Protein PTOV1 homolog; It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
      
 0.526
ced-6
PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth.
      
 0.520
drpr
Protein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...]
      
 0.484
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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