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Jra protein (fruit fly) - STRING interaction network
"Jra" - Jun-related antigen in Drosophila melanogaster
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
JraJun-related antigen; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’ (PubMed-1696724, PubMed-2116361). Plays a role in dorsal closure (PubMed-9224723) (372 aa)    
Predicted Functional Partners:
kay
Kayak; Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence- 5’-TGA[CG]TCA-3’. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra (755 aa)
     
  0.999
bsk
Basket; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure (372 aa)
       
  0.999
Atf3
Activating transcription factor 3; Transcription factor which binds to the cAMP response element (CRE) (PubMed-20023169). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut (PubMed-22851689). Required for the expression of odorant receptors Or43b and Or47b (PubMed-26848073) (688 aa)
     
0.978
rl
Rolled; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Required for embryonic epithelial tissue repair (376 aa)
       
  0.976
CrebB
Cyclic-AMP response element binding protein B at 17A; Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters (359 aa)
       
  0.956
puc
Puckered (476 aa)
     
  0.954
Atf-2
Activating transcription factor-2 (850 aa)
     
  0.953
dpp
Decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is res [...] (588 aa)
         
  0.951
peb
Pebbled (1894 aa)
       
  0.950
raw
Raw (989 aa)
     
  0.941
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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