STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AmnionlessProtein amnionless; Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Cubn. (505 aa)    
Predicted Functional Partners:
CG42255
Uncharacterized protein; Calcium ion binding.
   
  
 0.954
Cubn
Cubilin homolog; Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless.
   
  
 0.952
CG34402
Uncharacterized protein, isoform C.
     
  0.900
CG34296
GEO10215p1.
      
 0.896
Klf15
Kruppel-like factor 15; Sequence-specific DNA binding; transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; nephrocyte diaphragm assembly; pericardial nephrocyte differentiation; response to silver ion; garland nephrocyte differentiation.
   
  
 0.680
Muc68E
Mucin 68E; Extracellular matrix structural constituent; chitin binding. It is involved in the biological process described with: chitin metabolic process.
      
 0.603
sns
Sticks and stones (sns) encodes a single-pass transmembrane protein of the immunoglobulin superfamily, which mediates cell-cell recognition and adhesion. The product of sns marks the fusion competent population of myoblasts. It also contributes to formation and function of the nephrocyte diaphragm and cell sorting within the developing ommatidia.
      
 0.601
Hex-A
Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis.
      
 0.523
Est-Q
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
      
 0.523
Mipp1
Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches. In these leading cells, enhances formation [...]
      
 0.522
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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