Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| 14-3-3zeta | Slob | FBpp0087500 | FBpp0303549 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.754 |
| 14-3-3zeta | slo | FBpp0087500 | FBpp0303318 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | Calcium-activated potassium channel slowpoke; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob [...] | 0.559 |
| 2mit | Slob | FBpp0303176 | FBpp0303549 | 2mit, isoform B; 2mit (2mit) encodes a putative leucine-rich repeat transmembrane protein that is mainly expressed in the developing central nervous system. In the adult, it has a role in short-term memory. | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.441 |
| CG33310 | Slob | FBpp0310272 | FBpp0303549 | Uncharacterized protein; ATPase activator activity; sodium:potassium-exchanging ATPase activity. It is involved in the biological process described with: cellular potassium ion homeostasis; cellular sodium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane. | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.666 |
| CG33310 | wake | FBpp0310272 | FBpp0310776 | Uncharacterized protein; ATPase activator activity; sodium:potassium-exchanging ATPase activity. It is involved in the biological process described with: cellular potassium ion homeostasis; cellular sodium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane. | Wide awake, isoform G; Wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. | 0.670 |
| Clk | Slob | FBpp0099478 | FBpp0303549 | Circadian locomoter output cycles protein kaput; Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced [...] | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.442 |
| Clk | wake | FBpp0099478 | FBpp0310776 | Circadian locomoter output cycles protein kaput; Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced [...] | Wide awake, isoform G; Wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. | 0.588 |
| Flo2 | Slob | FBpp0303248 | FBpp0303549 | Flotillin-2; Flotillin 2 (Flo2) encodes encodes a scaffold protein that contributes to the anti-parasitoid immune response and the secretion and spreading of the ligands encoded by wg and hh; Belongs to the band 7/mec-2 family. Flotillin subfamily. | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.450 |
| Hug | Slob | FBpp0082108 | FBpp0303549 | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.430 |
| NijA | Slob | FBpp0089001 | FBpp0303549 | Ninjurin A (NijA) encodes a transmembrane protein of the conserved Ninjurin family. It is upregulated in response to injury and infection, suggesting a role in immune or stress responses. When overexpressed the product of NijA causes cell death. | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 0.430 |
| Slob | 14-3-3zeta | FBpp0303549 | FBpp0087500 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | 0.754 |
| Slob | 2mit | FBpp0303549 | FBpp0303176 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | 2mit, isoform B; 2mit (2mit) encodes a putative leucine-rich repeat transmembrane protein that is mainly expressed in the developing central nervous system. In the adult, it has a role in short-term memory. | 0.441 |
| Slob | CG33310 | FBpp0303549 | FBpp0310272 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Uncharacterized protein; ATPase activator activity; sodium:potassium-exchanging ATPase activity. It is involved in the biological process described with: cellular potassium ion homeostasis; cellular sodium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane. | 0.666 |
| Slob | Clk | FBpp0303549 | FBpp0099478 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Circadian locomoter output cycles protein kaput; Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced [...] | 0.442 |
| Slob | Flo2 | FBpp0303549 | FBpp0303248 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Flotillin-2; Flotillin 2 (Flo2) encodes encodes a scaffold protein that contributes to the anti-parasitoid immune response and the secretion and spreading of the ligands encoded by wg and hh; Belongs to the band 7/mec-2 family. Flotillin subfamily. | 0.450 |
| Slob | Hug | FBpp0303549 | FBpp0082108 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.430 |
| Slob | NijA | FBpp0303549 | FBpp0089001 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Ninjurin A (NijA) encodes a transmembrane protein of the conserved Ninjurin family. It is upregulated in response to injury and infection, suggesting a role in immune or stress responses. When overexpressed the product of NijA causes cell death. | 0.430 |
| Slob | eag | FBpp0303549 | FBpp0110308 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Potassium voltage-gated channel protein eag; Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve. | 0.437 |
| Slob | slo | FBpp0303549 | FBpp0303318 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Calcium-activated potassium channel slowpoke; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob [...] | 0.952 |
| Slob | wake | FBpp0303549 | FBpp0310776 | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. | Wide awake, isoform G; Wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. | 0.678 |
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