Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...]

LD36772p; poly(U) RNA binding; mRNA 3'-UTR binding; mRNA binding; poly(A) binding; RNA binding. It is involved in the biological process described with: long-term memory; positive regulation of translation.

GH11843p; It is involved in the biological process described with: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation.

Purine-rich binding protein-alpha (Pur-alpha) encodes a DNA- and RNA-binding protein involved in the regulation of transcription and cell-cycle. In the cytoplasm it is found in motile RNPs, indicating a role in RNA localization.

Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family.

Symplekin (Sym) encodes a large protein that contains many protein interaction sites, and acts as a scaffold for protein complexes in the nucleus. It functions in RNA 3' end formation for both polyadenyated mRNAs and non-polyadenylated histone mRNAs. In some cells it also localizes to the cell cortex, especially the tricellular junctions of some epithelia.

Hiiragi, isoform D; Hiiragi (hrg) encodes the canonical poly(A) polymerase required for the nuclear poly(A) tail synthesis at the mRNA 3'-end. hrg product is also involved in cytoplasmic polyadenylation of specific mRNAs during early to mid-oogenesis, through its interaction with the CPEB (cytoplasmic polyadenylation element binding) protein encoded by orb.

ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...]

GLD2 poly(A) polymerase (Gld2) encodes a conserved poly-A polymerase in the GLD2 family. It is a paralog of the wisp gene. Gld2 is expressed strongly in the testis and at low levels in other tissues including the nervous system. In the male germ line, the product of Gld2 is essential for postmeiotic development of sperm; its depletion causes arrest of spermatogenesis prior to individualization, with abnormal nuclear condensation phenotypes. In the brain it is required for long-term memory.