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chrb protein (fruit fly) - STRING interaction network
"chrb" - Protein charybde in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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chrbProtein charybde; Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development; Belongs to the DDIT4 family (299 aa)    
Predicted Functional Partners:
gig
Gigas, isoform A; GTPase activator activity; Ras GTPase activator activity; protein binding; kinase binding (1847 aa)
         
  0.929
14-3-3zeta
14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo- binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3- phosphate and promotes maturation of early endosomes (248 aa)
     
    0.909
SR3-9
14-3-3epsilon is an acidic protein that preferentially heterodimerizes with other members of the family but also can homodimerize. It functions in multiple signaling pathways, most prominently in the Ras/MAPK cascade. It is involved in embryonic hatching, germ cell migration, gonad formation, wing venation and eye development; Belongs to the 14-3-3 family (262 aa)
       
    0.903
pAbp
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA; Belongs to the polyadenylate-binding protein type-1 family (634 aa)
     
 
  0.793
nonC
Serine/threonine-protein kinase Smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1; Belongs to the PI3/PI4-kinase family (3218 aa)
       
 
  0.768
Cbp20
Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...] (154 aa)
       
      0.764
Upf1
Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity) (1180 aa)
       
      0.764
Upf3
Upf3, isoform B; Nucleotide binding. It is involved in the biological process described with- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (492 aa)
       
      0.764
Upf2
RE04053p; Upf2 is required for nonsense-mediated mRNA decay (NMD). Upf2 interacts directly with Upf1 to identify and degrade NMD-substrate mRNAs, including mRNAs containing premature termination codons and a number of normal endogenous mRNAs (1241 aa)
       
      0.764
Las
Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family (377 aa)
           
  0.680
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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