node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arr2 | CG32683 | FBpp0076326 | FBpp0071397 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | 0.502 |
Arr2 | Gprk2 | FBpp0076326 | FBpp0085149 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.789 |
Arr2 | Octbeta1R | FBpp0076326 | FBpp0304263 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Octopamine receptor beta-1R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production. Antagonizes the action of Octbeta2R which stimulates synaptic growth. | 0.555 |
Arr2 | Octbeta2R | FBpp0076326 | FBpp0303153 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R. | 0.555 |
Arr2 | Octbeta3R | FBpp0076326 | FBpp0288773 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Octopamine receptor beta-3R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis. Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis. Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes. Belongs to the G-protein coupled receptor 1 family. | 0.555 |
Arr2 | Syt1 | FBpp0076326 | FBpp0077410 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. | 0.514 |
Arr2 | nSyb | FBpp0076326 | FBpp0303878 | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. | 0.529 |
CG32683 | Arr2 | FBpp0071397 | FBpp0076326 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.502 |
CG32683 | Gprk2 | FBpp0071397 | FBpp0085149 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.716 |
CG32683 | Octbeta1R | FBpp0071397 | FBpp0304263 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | Octopamine receptor beta-1R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production. Antagonizes the action of Octbeta2R which stimulates synaptic growth. | 0.563 |
CG32683 | Octbeta2R | FBpp0071397 | FBpp0303153 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R. | 0.556 |
CG32683 | Octbeta3R | FBpp0071397 | FBpp0288773 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | Octopamine receptor beta-3R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis. Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis. Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes. Belongs to the G-protein coupled receptor 1 family. | 0.563 |
CG32683 | Syt1 | FBpp0071397 | FBpp0077410 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. | 0.514 |
CG32683 | nSyb | FBpp0071397 | FBpp0303878 | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. | 0.524 |
CG7058 | Octbeta1R | FBpp0290376 | FBpp0304263 | GH01369p; Ubiquitin protein ligase binding. It is involved in the biological process described with: regulation of proteolysis; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. | Octopamine receptor beta-1R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production. Antagonizes the action of Octbeta2R which stimulates synaptic growth. | 0.608 |
CG7058 | Octbeta2R | FBpp0290376 | FBpp0303153 | GH01369p; Ubiquitin protein ligase binding. It is involved in the biological process described with: regulation of proteolysis; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. | Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R. | 0.527 |
Gprk2 | Arr2 | FBpp0085149 | FBpp0076326 | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception. | 0.789 |
Gprk2 | CG32683 | FBpp0085149 | FBpp0071397 | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization. | 0.716 |
Gprk2 | Octbeta1R | FBpp0085149 | FBpp0304263 | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Octopamine receptor beta-1R; Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production. Antagonizes the action of Octbeta2R which stimulates synaptic growth. | 0.580 |
Gprk2 | Octbeta2R | FBpp0085149 | FBpp0303153 | G protein-coupled receptor kinase 2 (Gprk2) encodes a member of a family of serine/threonine kinases that modulate G-protein coupled receptors. It is required for female fertility, normal egg shape, and normal egg cAMP levels. It is also implicated in Hedgehog signaling and olfactory rhythmicity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R. | 0.580 |