node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdk8 | wac | FBpp0076098 | FBpp0304416 | Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C- terminal domain) of th [...] | Augmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] | 0.552 |
Grip71 | dgt2 | FBpp0080649 | FBpp0309535 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | 0.517 |
Grip71 | dgt3 | FBpp0080649 | FBpp0271922 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | 0.808 |
Grip71 | dgt4 | FBpp0080649 | FBpp0305385 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit dgt4; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. | 0.611 |
Grip71 | dgt5 | FBpp0080649 | FBpp0087059 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit dgt5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. | 0.777 |
Grip71 | dgt6 | FBpp0080649 | FBpp0084783 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit dgt6; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules ; Belongs to the HAUS6 family. | 0.807 |
Grip71 | gammaTub37C | FBpp0080649 | FBpp0304827 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Tubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. Required for oocyte activation and consequently for organization of the female meiotic spindle. Essential for centrosome organization and assembly of biastral mitotic spindles in embryos. Plays a role in stabilizing the augmin complex on the meiotic spindle. | 0.952 |
Grip71 | msd1 | FBpp0080649 | FBpp0072571 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit msd1; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle. | 0.534 |
Grip71 | msd5 | FBpp0080649 | FBpp0072608 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit msd5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. | 0.451 |
Grip71 | wac | FBpp0080649 | FBpp0304416 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | Augmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] | 0.800 |
dgt2 | Grip71 | FBpp0309535 | FBpp0080649 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | 0.517 |
dgt2 | dgt3 | FBpp0309535 | FBpp0271922 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | 0.964 |
dgt2 | dgt4 | FBpp0309535 | FBpp0305385 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit dgt4; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. | 0.956 |
dgt2 | dgt5 | FBpp0309535 | FBpp0087059 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit dgt5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. | 0.976 |
dgt2 | dgt6 | FBpp0309535 | FBpp0084783 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit dgt6; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules ; Belongs to the HAUS6 family. | 0.985 |
dgt2 | msd1 | FBpp0309535 | FBpp0072571 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit msd1; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle. | 0.986 |
dgt2 | msd5 | FBpp0309535 | FBpp0072608 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit msd5; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. | 0.969 |
dgt2 | wac | FBpp0309535 | FBpp0304416 | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | Augmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] | 0.984 |
dgt3 | Grip71 | FBpp0271922 | FBpp0080649 | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. | 0.808 |
dgt3 | dgt2 | FBpp0271922 | FBpp0309535 | Augmin complex subunit dgt3; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules ; Belongs to the HAUS3 family. | Augmin complex subunit dgt2; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt2 binds to microtubules in vitro. | 0.964 |