STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
trcSerine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons. Belongs to the protein kinase supe [...] (463 aa)    
Predicted Functional Partners:
mats
MOB kinase activator-like 1; Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits th [...]
   
 
 0.971
cdc14
Cell division cycle 14, isoform A; Protein tyrosine/serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity.
   
 
 0.953
Mob2
Mob2 (Mob2) encodes a protein that belongs to the Mob1/phocein domain protein family. Its functions include rhabdomere determination during photoreceptor development.
    
 
 0.943
GckIII
Germinal centre kinase III (GckIII) encodes a serine/threonine kinase of the STE20 superfamily. It is the sole Drosophila germinal center kinase type 3 family member. Loss of GckIIII results in tube dilation defects that are specific to the terminal cells of the tracheal system.
  
 
 
0.849
Pka-R2
cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain.
 
 
 
 0.847
Mrtf
Myocardin-related transcription factor (Mrtf) encodes a protein that binds to the product of bs, and likely other transcription factors, to enhance downstream gene activation. The activity of the product of Mrtf is regulated by free actin levels. It contributes to tracheal branching, border cell migration, and other cell stretching and invasive migration processes during development.
   
 
 0.841
fry
Protein furry; Trc/fry signaling pathway plays a key role in maintaining the integrity of polarized cell extensions (arista) during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. Fry positively regulates trc kinase activity.
    
 
 0.814
Dis3
Dis3, isoform A; Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance; Belongs to the RNR ribonuclease family.
   
 
 0.793
Dis3l2
Dis3 like 3'-5' exoribonuclease 2 (Dis3l2) encodes a 3'-5'-exoribonuclease involved in catabolism of miRNA and tRNA; Belongs to the RNR ribonuclease family.
    
 
 0.792
tws
Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
   
 
 0.789
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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