STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CdGAPrCd GTPase activating protein-related (CdGAPr) encodes a protein that acts in concert with the product of Fak in the formation of the optic stalk, a tubular structure composed of glial cells. (1843 aa)    
Predicted Functional Partners:
GEFmeso
Guanine nucleotide exchange factor in mesoderm (GEFmeso) encodes a protein that regulates the products of Rala and Cdc42. It is involved in leg morphogenesis and wing vein specification.
     
 0.766
CG6424
Uncharacterized protein, isoform A.
   
 
 0.758
RhoGAP54D
Rho GTPase activating protein at 54D, isoform A; GTPase activator activity. It is involved in the biological process described with: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; imaginal disc-derived leg morphogenesis.
   
 
 0.718
RhoU
RhoU, isoform B; GTPase activity; protein kinase binding; GTP binding.
    
 0.715
gek
Serine/threonine-protein kinase Genghis Khan; Acts as a downstream effector for the regulation of actin polymerization by Cdc42.
   
 0.710
conu
Rho GTPase-activating protein conundrum; GTPase-activating protein (GAP) for Rho1; functions with the ERM protein Moe to regulate Rho1 and control proliferation in the developing epithelium. Recruited by Moe to the cell cortex where it negatively regulates Rho1 activity. Can also promote cell proliferation independently of its GAP activity, perhaps by acting with Arf51F (Arf6) to positively regulate Rac1.
   
 
 0.686
CG16896
LD44910p; GTPase activator activity. It is involved in the biological process described with: regulation of GTPase activity.
      
 0.668
mah
Mahogany; Amino acid transmembrane transporter activity. It is involved in the biological process described with: amino acid transmembrane transport.
      
 0.650
RhoGAP71E
Rho GTPase activating protein at 71E (RhoGAP71E) encodes a Rho GTPase activating protein that is involved in the regulation of actin dynamics during epithelial morphogenesis.
   
 
 0.639
CG12056
Neuferricin homolog; Heme-binding protein.
      
 0.633
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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