STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RilplRILP-like protein homolog; May have a role in lysosome distribution by interacting with Arl8; Belongs to the RILPL family. (486 aa)    
Predicted Functional Partners:
Osi2
Osiris 2, isoform A.
      
 0.791
CG2556
RE14150p.
      
 0.674
CG13760
RE44620p.
   
  
 0.669
Arl8
ADP-ribosylation factor-like protein 8; Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion. Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes. In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Essential role in chromosome segregation.
    
 
 0.648
CG31038
Uncharacterized protein, isoform A.
      
 0.630
Rab35
Rab35, isoform A; Rab35 (Rab35) encodes a protein that regulates proximal versus distal growth of seamless tubes in the terminal cells of the tracheal system.
   
  
 0.629
Rint1
RINT1-like protein; During cytokinesis in male meiotic cells, required for completion of cleavage furrow ingression possibly in conjunction with Zw10. Required for maintenance of Golgi stack number and morphology. Essential for acroblast assembly.
      
 0.622
CG17598
GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.
   
  
 0.615
CG32425
LD41948p.
      
 0.610
Iris
GH26159p.
    
   0.596
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.