STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UK114RutC family protein UK114; Molecular chaperone. Seems to fulfill an ATP-independent, HSP70-like function in protein folding. May protect essential factors of cell proliferation during heat shock. No role in calpain activation. (138 aa)    
Predicted Functional Partners:
Cnot4
CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E.
    
 
 0.696
CG14740
Citrate (Si)-synthase activity. It is involved in the biological process described with: carbohydrate metabolic process; tricarboxylic acid cycle.
  
  
 0.680
CalpB
Calpain-B catalytic subunit 1; Calcium-regulated non-lysosomal thiol-protease.
      
 0.665
Not1
Not1, isoform H; Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development.
    
 
 0.650
kdn
Probable citrate synthase, mitochondrial; Plays a role in controlling neuronal activity and seizure susceptibility; Belongs to the citrate synthase family.
  
  
 0.641
Rrp42
IP10364p; AU-rich element binding.
    
   0.612
CalpA
Calpain-A catalytic subunit; Calpain-A (CalpA) encodes a calcium-dependent modulatory protease that cleaves its substrates in a limited fashion. During patterning and division in the blastoderm embryo, CalpA product cleaves the NF-kappaB inhibitor and the cell cycle regulator encoded by cact and CycB, respectively. CalpA product also regulates dendritic prunning of sensory neurons.
      
 0.607
Not3
CCR4-NOT transcription complex subunit 3 (Not3) encodes a poly(A)-specific ribonuclease involved in translation inhibition.
    
 
 0.568
Ythdf
YTH domain-containing family protein; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability.
    
 
 0.553
Dph3
DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
      
 0.528
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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