| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG4078 | Mat1 | FBpp0304672 | FBpp0087350 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | 0.848 |
| CG4078 | Mlh1 | FBpp0304672 | FBpp0087867 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | 0.969 |
| CG4078 | Mms19 | FBpp0304672 | FBpp0078425 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | GH06271p; It is involved in the biological process described with: iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer. | 0.856 |
| CG4078 | Ssl1 | FBpp0304672 | FBpp0078205 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding. | 0.858 |
| CG4078 | Tfb1 | FBpp0304672 | FBpp0086678 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.848 |
| CG4078 | Tfb4 | FBpp0304672 | FBpp0077650 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity. | 0.839 |
| CG4078 | hay | FBpp0304672 | FBpp0075982 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.854 |
| CG4078 | mre11 | FBpp0304672 | FBpp0079802 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.914 |
| CG4078 | mus101 | FBpp0304672 | FBpp0073648 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | Mutagen-sensitive 101 (mus101) encodes a protein involved in the DNA replication checkpoint during mitosis. | 0.944 |
| CG4078 | nbs | FBpp0304672 | FBpp0297182 | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | Nibrin; Nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions. | 0.903 |
| Mat1 | CG4078 | FBpp0087350 | FBpp0304672 | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | 0.848 |
| Mat1 | Ssl1 | FBpp0087350 | FBpp0078205 | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding. | 0.999 |
| Mat1 | Tfb1 | FBpp0087350 | FBpp0086678 | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.999 |
| Mat1 | Tfb4 | FBpp0087350 | FBpp0077650 | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity. | 0.997 |
| Mat1 | hay | FBpp0087350 | FBpp0075982 | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.999 |
| Mlh1 | CG4078 | FBpp0087867 | FBpp0304672 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | 0.969 |
| Mlh1 | hay | FBpp0087867 | FBpp0075982 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.820 |
| Mlh1 | mre11 | FBpp0087867 | FBpp0079802 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.616 |
| Mlh1 | nbs | FBpp0087867 | FBpp0297182 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | Nibrin; Nbs (nbs) encodes a component of the conserved MRN complex, which plays an important role in the repair of DNA double strand breaks. The product of nbs is required to prevent chromosome breakage, interacts with the telomere capping complex and prevents telomeric fusions. | 0.668 |
| Mms19 | CG4078 | FBpp0078425 | FBpp0304672 | GH06271p; It is involved in the biological process described with: iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer. | Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. | 0.856 |