STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asrijOCIA domain-containing protein 1; Asrij (asrij) encodes a conserved ovarian carcinoma immunoreactive antigen domain-containing endosomal protein that maintains stemness. It positively regulates JAK/STAT signalling and negatively regulates the Notch pathway. It interacts with the GTP-bound form of the product of Arf79F to regulate hematopoiesis and immunity; Belongs to the OCIAD1 family. (258 aa)    
Predicted Functional Partners:
Arf79F
ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells.
    
 
 0.792
CG17327
MIP04754p; aminoacyl-tRNA hydrolase activity.
   
 
 0.769
CG30423
RH04491p; Signaling receptor binding. It is involved in the biological process described with: negative regulation of receptor signaling pathway via JAK-STAT; late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface.
      
 0.680
140up
RPII140-upstream gene protein; Essential for viability.
   
 
 0.627
Arfip
Arfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development.
      
 0.603
CG6693
J domain-containing protein CG6693; Heat shock protein binding.
      
 0.603
CG3008
Serine/threonine-protein kinase RIO3; Protein serine/threonine kinase activity; protein kinase activity; ATP binding. It is involved in the biological process described with: protein phosphorylation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
   
  
 0.538
SCCRO4
Defective in cullin neddylation protein; Squamous cell carcinoma-related oncogene 4 (SCCRO4) encodes a protein involved in the regulation of protein neddylation.
      
 0.528
kn
Transcription factor collier; May act as a 'second-level regulator' of head patterning. Required for establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment. Required for expression of the segment polarity genes hedgehog, engrailed and wingless, and the segment-identity genes CAP and collar in the intercalary segment. Required at the onset of the gastrulation for the correct formation of the mandibular segment.
    
 
 0.511
EMC10
Uncharacterized protein, isoform C.
   
  
 0.507
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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