STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
encProtein encore; Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex. (1942 aa)    
Predicted Functional Partners:
GC2
Glutamate carrier 2, isoform B; Glutamate Carrier 2 (GC2) encodes a protein of the inner mitochondrial membrane that catalyzes the transport of L-glutamate across the inner mitochondrial membrane. GC2 expression is confined to the testes.
      
 0.797
grk
Protein gurken; Critical for defining the anterior-posterior and dorsal- ventral axes of the egg. May signal directly to dorsal follicle cells through the receptor torpedo (top). During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway.
    
 
 0.673
sqd
RNA-binding protein squid; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues.
   
  
 0.593
CG16952
Uncharacterized protein, isoform H.
   
  
 0.569
CASK
Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity.
   
 
 0.564
CG11593
Uncharacterized protein, isoform B; Exopolyphosphatase activity. It is involved in the biological process described with: polyphosphate catabolic process.
   
  
 0.543
UQCR-C1
Metalloendopeptidase activity; ubiquinol-cytochrome-c reductase activity; metal ion binding; endopeptidase activity. It is involved in the biological process described with: protein processing; protein processing involved in protein targeting to mitochondrion; mitochondrial electron transport, ubiquinol to cytochrome c.
   
 
 0.535
CG13604
Protein UBASH3A homolog; Phosphatase activity. It is involved in the biological process described with: dephosphorylation.
      
 0.510
CycE
G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.
   
 
 0.509
Rdh
Red herring.
      
 0.491
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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