node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB7 | CG11836 | FBpp0072637 | FBpp0423042 | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. | Uncharacterized protein, isoform J; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. | 0.669 |
ABCB7 | IscU | FBpp0072637 | FBpp0081412 | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.933 |
ABCB7 | bcn92 | FBpp0072637 | FBpp0070415 | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. | Protein bcn92; It is involved in the biological process described with: iron-sulfur cluster assembly; Belongs to the complex I LYR family. | 0.851 |
ABCB7 | comt | FBpp0072637 | FBpp0073585 | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. | 0.674 |
CG11836 | ABCB7 | FBpp0423042 | FBpp0072637 | Uncharacterized protein, isoform J; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. | 0.669 |
CG11836 | comt | FBpp0423042 | FBpp0073585 | Uncharacterized protein, isoform J; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. | 0.667 |
IscU | ABCB7 | FBpp0081412 | FBpp0072637 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. | 0.933 |
IscU | bcn92 | FBpp0081412 | FBpp0070415 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Protein bcn92; It is involved in the biological process described with: iron-sulfur cluster assembly; Belongs to the complex I LYR family. | 0.999 |
IscU | comt | FBpp0081412 | FBpp0073585 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. | 0.689 |
Snap24 | Snap25 | FBpp0081641 | FBpp0110435 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | 0.867 |
Snap24 | Syx13 | FBpp0081641 | FBpp0304386 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. | Syntaxin 13 (Syx13) encodes a member of the syntaxin family of t-SNAREs that mediate vesicle fusion within cells. It localizes to endosomes and is involved in autophagosome maturation. | 0.896 |
Snap24 | Syx1A | FBpp0081641 | FBpp0292260 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. | Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Required for coordinated peristaltic contractions. Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens [...] | 0.999 |
Snap24 | alphaSnap | FBpp0081641 | FBpp0074609 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Also between the endosome and phagosome. | 0.990 |
Snap24 | comt | FBpp0081641 | FBpp0073585 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. | 0.761 |
Snap25 | Snap24 | FBpp0110435 | FBpp0081641 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. | 0.867 |
Snap25 | Syx13 | FBpp0110435 | FBpp0304386 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | Syntaxin 13 (Syx13) encodes a member of the syntaxin family of t-SNAREs that mediate vesicle fusion within cells. It localizes to endosomes and is involved in autophagosome maturation. | 0.870 |
Snap25 | Syx1A | FBpp0110435 | FBpp0292260 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Required for coordinated peristaltic contractions. Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens [...] | 0.999 |
Snap25 | alphaSnap | FBpp0110435 | FBpp0074609 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Also between the endosome and phagosome. | 0.990 |
Snap25 | comt | FBpp0110435 | FBpp0073585 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. | 0.740 |
Snap25 | shi | FBpp0110435 | FBpp0305866 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.501 |