STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nse1Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double- strand breaks (By similarity); Belongs to the NSE1 family. (235 aa)    
Predicted Functional Partners:
MAGE
RE25453p; MAGE (MAGE) encodes a component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes.
   
 0.999
jnj
Java no jive (jnj) encodes the Smc6 subunit of the SMC5/6 protein complex. It is involved genotoxic stress and response to caffeine.
    
 0.999
Nse4
Non-SMC element 4 (Nse4) encodes a member of the EID (EP300-interacting inhibitor of differentiation) family of proteins. It is the kleisin component of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes.
   
 0.999
SMC5
Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes.
    
 0.999
qjt
Quijote, isoform A; Quijote (qjt) encodes a SUMO E3 ligase and a highly conserved subunit of the Smc5/6 complex. It is enriched in heterochromatin and recruited to heterochromatic double-strand break repair sites.
    
 0.993
cerv
Cervantes, isoform A; Zinc ion binding; SUMO transferase activity. It is involved in the biological process described with: DNA repair; double-strand break repair via homologous recombination.
   
 0.947
CG42299
IP07325p; SUMO transferase activity; zinc ion binding. It is involved in the biological process described with: double-strand break repair via homologous recombination.
    
 0.911
CG42300
MIP26115p; Zinc ion binding; SUMO transferase activity. It is involved in the biological process described with: double-strand break repair via homologous recombination.
    
 0.911
SMC2
Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation.
   
 
 0.868
glu
Structural maintenance of chromosomes protein; Gluon (glu) encodes a subunit of the multiprotein complex condensin that is required for chromosome condensation and sister chromatid segregation. It contributes to nervous system development and glucose metabolism.
   
 
 0.750
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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