STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cpr78CbCuticular protein 78Cb, isoform A; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development. (140 aa)    
Predicted Functional Partners:
CG9215
RH47711p; Zinc ion binding; DNA-binding transcription factor activity; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II.
    
 
 0.843
CG14427
RE73396p.
      
 0.835
CG8289
LD36501p.
    
 
 0.696
CG12420
Uncharacterized protein.
      
 0.680
yem
Yemanuclein (yem) is a maternally expressed gene essential in the oocyte for meiosis and in the zygote for male pronucleus chromatin assembly. yem encodes a chaperone of H3.3 histone variant in partnership with the protein encoded by Hira. It also interacts with components of the Cohesin and the synaptonemal complexes.
    
 
 0.631
Cda4
Chitin deacetylase-like 4; Chitin binding. It is involved in the biological process described with: chitin metabolic process; carbohydrate metabolic process.
   
  
 0.630
CenG1A
Centaurin-gamma-1A; Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent.
      
 0.608
Bap60
Brahma-associated protein of 60 kDa; Involved in the recruitment and site-specific anchoring of the Brahma complex at specific promoter sites. The Brahma complex is a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Participates in X-chromosomal dosage compensation. Participates in neurogenesis.
   
 
 0.587
polybromo
Polybromo (polybromo) encodes a subunit of Polybromo-associated Brahma complex (PBAP). Its main biological role is involved in chromatin remodeling together with Brahma complex. It can also regulate gene transcription through DNA binding, which is dependent or independent ofthe PBAP complex.
   
 
 0.587
Snr1
Snf5-related 1 (Snr1) encodes a core component of the ATP-dependent SWI/SNF chromatin-remodeling complex (Brahma complex). It functions as a tumor suppressor and is required for maintaining normal endosomal trafficking-mediated signaling cascades; Belongs to the SNF5 family.
   
 
 0.584
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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