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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rsf1RNA-binding protein Rsf1; May control important aspects of development. (200 aa)    
Predicted Functional Partners:
SF2
Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism.
  
 
0.972
tra2
Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...]
  
 
 0.938
SC35
SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site.
  
 
0.850
Rbp1
RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family.
  
 
0.848
x16
X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation.
  
 
0.839
Rbp1-like
Rbp1-like, isoform B; Rbp1-like (Rbp1-like) encodes a mRNA binding protein involved in RNA splicing and RNA metabolism.
  
 
0.837
rump
Rumpelstiltskin, isoform A; Rumpelstiltskin (rump) encodes the Drosophila hnRNP M homolog. It binds to nos and osk mRNAs and plays a role in mRNA localization to the germ plasm by diffusion/entrapment during late stages of oogenesis. It also binds to exonic splicing enhancers on pre-mRNA targets, implicating it as a splicing factor.
  
 
 0.782
Rox8
Rox8, isoform D; Rox8 (Rox8) encodes a protein involved in the regulation of alternative mRNA splicing.
  
 
 0.747
tsu
RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte. Belongs to the RBM8A family.
   
 
 0.679
snRNP-U1-70K
Small ribonucleoprotein particle U1 subunit 70K (snRNP-U1-70K) encodes a protein component of the U1 snRNP. The U1 snRNP combines with other snRNPs on the pre-mRNA to assemble a spliceosome.
   
 
 0.675
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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