STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tutlTurtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control; Belongs to the immunoglobulin superfamily. Turtle family. (1536 aa)    
Predicted Functional Partners:
bdl
Borderless (bdl) encodes a cell adhesion molecule that is required for glial extension and axon ensheathment. Its down-regulation by the products of tutl and Lar is required for photoreceptor axonal tiling and layer-specific target selection; Belongs to the immunoglobulin superfamily.
  
 
0.633
CG34136
HDC03535.
      
 0.603
CG4467
Uncharacterized protein, isoform B; Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: peptide catabolic process; proteolysis.
   
  
 0.544
CG11147
RH61964p; ATPase activity; ATP binding. It is involved in the biological process described with: transmembrane transport.
    
 
 0.541
CadN
Neural-cadherin; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
   
 
 0.528
CG6693
J domain-containing protein CG6693; Heat shock protein binding.
      
 0.521
ths
Thisbe, isoform A; Thisbe (ths) encodes is a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival.
   
 
 0.511
CG15270
Anoctamin; Intracellular calcium activated chloride channel activity; calcium activated cation channel activity. It is involved in the biological process described with: chloride transport; cation transport; transmembrane transport.
   
  
 0.509
CG5521
Probable Rho GTPase-activating protein CG5521; GTPase activator activity. It is involved in the biological process described with: regulation of small GTPase mediated signal transduction; positive regulation of GTPase activity.
   
  
 0.507
CG13175
GEO13458p1.
      
 0.497
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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