STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Tom40Mitochondrial import receptor subunit TOM40 homolog 1; Translocase of outer membrane 40 (Tom40) encodes a protein predicted to be a channel component of the TOM complex, which is involved in protein import into mitochondria. It is predicted to be involved in the cellular response to hypoxia. (344 aa)    
Predicted Functional Partners:
Tom70
Translocase of outer membrane 70 (Tom70) encodes a mitochondrial protein that may act as a receptor of the TOM complex based on orthology. TOM complex is involved in protein import into mitochondria. The product of Tom70 modulates cell death induced by the expression of the mouse Bax protein.
   
 0.998
Tom20
Translocase of outer membrane 20, isoform A; Mitochondrion targeting sequence binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein targeting to mitochondrion; tRNA import into mitochondrion; mitochondrial outer membrane translocase complex assembly; protein import into mitochondrial matrix.
   
 0.997
Tom7
Translocase of outer membrane 7 (Tom7) encodes a putative mitochondrial protein that may act as a channel component of the TOM complex based on orthology with the human gene TOMM7.
   
 0.997
CG9393
Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family.
   
 0.953
mge
Mitochondrial import protein; Maggie (mge) encodes a protein predicted to act as a receptor of the TOM (translocase of outer membrane) complex, which is involved in protein import into mitochondria. The product of mge modulates cell death induced by the expression of the mouse Bax protein.
   
 0.951
tomboy20
GEO10511p1; P-P-bond-hydrolysis-driven protein transmembrane transporter activity; mitochondrion targeting sequence binding. It is involved in the biological process described with: protein targeting to mitochondrion; protein import into mitochondrial matrix; mitochondrial outer membrane translocase complex assembly; tRNA import into mitochondrion.
    
 0.929
CG7639
SAM50-like protein CG7639; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family.
   
 0.926
Pink1
PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain.
    
 
 0.894
porin
Voltage-dependent anion-selective channel; Porin (porin) encodes a beta-barrel channel protein localized in the outer membrane of mitochondria that conducts translocation of various ions and metabolites between cytoplasm and mitochondria. It plays roles in mitochondria dynamics and mitophagy, and is ubiquitinated by the E3 ligases encoded by park and Mul1.
   
 
 0.808
Tim10
Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family.
   
 
 0.803
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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