STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TetDNA N6-methyl adenine demethylase; Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)- methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression. Promotes differentiation of early germ cells in ovary. (2921 aa)    
Predicted Functional Partners:
shn
Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites.
   
  
 0.657
sxc
Super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing.
   
 
 0.627
CG5921
Uncharacterized protein, isoform D; Actin filament binding; spectrin binding. It is involved in the biological process described with: sensory perception of sound; G2/M transition of mitotic cell cycle.
      
 0.619
dia
Protein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function.
      
 0.603
Thd1
Double-stranded DNA binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; uracil DNA N-glycosylase activity. It is involved in the biological process described with: base-excision repair, AP site formation; mismatch repair.
   
  
 0.589
Lint-1
L(3)mbt interacting protein 1 (Lint-1) encodes a nuclear protein that associates with the product of l(3)mbt in the LINT complex. It is involved in the repression of malignant brain tumor signature (MBTS) genes.
      
 0.521
AdamTS-B
Uncharacterized protein, isoform B; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis; negative regulation of imaginal disc-derived wing vein specification; negative regulation of epidermal growth factor receptor signaling pathway.
   
  
 0.504
stl
Stall, isoform C; Stall (stl) encodes a protein involved in neuron migration inhibition and ovarian follicle development.
      
 0.499
htk
Hat-trick, isoform D; Transcription regulatory region sequence-specific DNA binding; chromatin binding; transcription cofactor binding; DNA-binding transcription factor binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; positive regulation of Notch signaling pathway.
   
 
 0.499
Lcp2
Larval cuticle protein 2; Component of the larval cuticle.
    
 
 0.499
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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