STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
snkyProtein sneaky; Component of the sperm acrosome membrane. Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization. (715 aa)    
Predicted Functional Partners:
mfr
Misfire, isoform F; Misfire (mfr) is a ferlin gene that encodes a protein involved in gamete generation.
   
  
 0.838
CG33262
Uncharacterized protein.
      
 0.835
ProtB
Protamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines.
   
  
 0.623
CG3815
GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated.
      
 0.529
CG34401
Uncharacterized protein, isoform C; Zinc ion binding. It is involved in the biological process described with: regulation of axon guidance.
      
 0.523
betaTub85D
Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family.
   
  
 0.511
Mst77F
Histone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I.
   
  
 0.510
fws
Conserved oligomeric Golgi complex subunit 5; Four way stop (fws) encodes a protein localised to the Golgi apparatus and involved in several aspects of spermatogenesis. Loss of function of fws causes failure of cleavage furrow ingression in dividing spermatocytes, as well as failure of cell elongation and disruption of the Golgi-based acroblast during spermatid differentiation.
      
 0.495
ProtA
Protamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines.
   
  
 0.488
ocn
BcDNA.GH02250; Protein histidine phosphatase activity. It is involved in the biological process described with: peptidyl-histidine dephosphorylation.
   
  
 0.484
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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