STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alpha-Man-IIaAlpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). (1109 aa)    
Predicted Functional Partners:
Mgat1
Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1) encodes an enzyme involved in the synthesis of paucimannose N-glycans. It is required in the CNS, with involvement in locomotion, brain development and lifespan.
   
 
 0.977
FucT6
Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated.
   
 0.962
beta'COP
Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
 
 
  
 0.888
Mppe
Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase.
    
 
 0.878
alpha-Man-IIb
alpha-Mannosidase class II b (alpha-Man-IIb) encodes a mannosidase involved in cellular encapsulation response and glycoprotein metabolism.
  
 
0.803
alpha-Man-Ic
alpha-1,2-Mannosidase; Calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. It is involved in the biological process described with: N-glycan processing; Belongs to the glycosyl hydrolase 47 family.
   
  
 0.748
FucTD
Alpha-(1->3)-fucosyltransferase activity. It is involved in the biological process described with: fucosylation; protein glycosylation.
      
 0.701
Gos28
Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (By similarity).
      
 0.691
GM130
Golgi matrix protein 130 kD (GM130) encodes a protein involved in Golgi compartmental organization and regulation of dendrite morphogenesis.
    
 
 0.680
alpha-Man-Ib
alpha-1,2-Mannosidase; Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding. It is involved in the biological process described with: encapsulation of foreign target; N-glycan processing; ubiquitin-dependent ERAD pathway; Belongs to the glycosyl hydrolase 47 family.
   
  
 0.662
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.