STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
beta-SpecBeta Spectrin (beta-Spec) encodes an essential protein that interacts with the product of alpha-Spec to form a heterotetramer. The product of beta-Spec is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. (2308 aa)    
Predicted Functional Partners:
alpha-Spec
Spectrin alpha chain; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi- derived membrane secretion [...]
   
0.998
Ank
Ankyrin, isoform B; Ankyrin (Ank) encodes protein that is recruited to the plasma membrane by its association with the product of beta-Spec. It also binds to the adhesion protein encoded by Nrg leading to accumulation of the products of Ank and beta-Spec at sites of cell-cell adhesion.
   
 0.895
CG13771
Uncharacterized protein, isoform A; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process.
      
 0.840
CG1635
LD44914p; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process.
      
 0.840
CG1774
GH08048p; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process.
      
 0.840
CG1638
Uncharacterized protein; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process.
      
 0.840
Ank2
Ankyrin 2, isoform U; Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis.
   
 
 0.794
nompC
No mechanoreceptor potential C (nompC) encodes a pore-forming subunit for a mechanosensitive non-selective cation channel. It belongs to the TRP channel family and is expressed in peripheral sensory neurons. It senses gentle touch and regulates locomotion in larval body wall neurons. In the adult, the product of nompC is involved in hearing transduction in the Johnston's organ.
   
 
 0.682
cora
Protein 4.1 homolog; An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development.
   
 
 0.647
Tnks
Tankyrase (Tnks) encodes an ADP-ribose polymerase that regulates Wnt signalling by contributing to the degradation of Axn.
   
 
 0.587
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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