Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cdk1 | Cdk2 | FBpp0079641 | FBpp0289675 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.731 |
| Cdk1 | CycA | FBpp0079641 | FBpp0075807 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | G2/mitotic-specific cyclin-A; Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. | 0.999 |
| Cdk1 | CycB | FBpp0079641 | FBpp0071822 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | G2/mitotic-specific cyclin-B; Cyclin B (CycB) encodes a protein that binds to Cdk1, thereby promoting Cdk1's protein kinase activity. The complex CycB-Cdk1 complex induces the start of mitosis. During late metaphase of mitosis and continuing in G1, the product of CycB is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity, and allowing termination of mitosis. | 0.999 |
| Cdk1 | CycE | FBpp0079641 | FBpp0294012 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex. | 0.961 |
| Cdk1 | Orc2 | FBpp0079641 | FBpp0082329 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.833 |
| Cdk1 | Wee1 | FBpp0079641 | FBpp0304607 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. | 0.997 |
| Cdk1 | grp | FBpp0079641 | FBpp0080443 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Serine/threonine-protein kinase grp; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...] | 0.626 |
| Cdk1 | lok | FBpp0079641 | FBpp0080860 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment. | 0.698 |
| Cdk1 | polo | FBpp0079641 | FBpp0074608 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. | 0.965 |
| Cdk1 | stg | FBpp0079641 | FBpp0306890 | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity. | 0.975 |
| Cdk2 | Cdk1 | FBpp0289675 | FBpp0079641 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cyclin-dependent kinase 1 (Cdk1) encodes a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3 products. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases. | 0.731 |
| Cdk2 | CycA | FBpp0289675 | FBpp0075807 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | G2/mitotic-specific cyclin-A; Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. | 0.999 |
| Cdk2 | CycB | FBpp0289675 | FBpp0071822 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | G2/mitotic-specific cyclin-B; Cyclin B (CycB) encodes a protein that binds to Cdk1, thereby promoting Cdk1's protein kinase activity. The complex CycB-Cdk1 complex induces the start of mitosis. During late metaphase of mitosis and continuing in G1, the product of CycB is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity, and allowing termination of mitosis. | 0.944 |
| Cdk2 | CycE | FBpp0289675 | FBpp0294012 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex. | 0.999 |
| Cdk2 | Orc2 | FBpp0289675 | FBpp0082329 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.976 |
| Cdk2 | Wee1 | FBpp0289675 | FBpp0304607 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. | 0.986 |
| Cdk2 | grp | FBpp0289675 | FBpp0080443 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Serine/threonine-protein kinase grp; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...] | 0.779 |
| Cdk2 | lok | FBpp0289675 | FBpp0080860 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment. | 0.697 |
| Cdk2 | polo | FBpp0289675 | FBpp0074608 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. | 0.710 |
| Cdk2 | stg | FBpp0289675 | FBpp0306890 | Cyclin-dependent kinase 2 (Cdk2) encodes a catalytic protein kinase subunit that can only become active after association with the product of CycE. The protein kinase activity of the CycE-Cdk2 complex controls important aspects of progression through the G1 and S phases of the cell cycle. In addition, periodic CycE-Cdk2 activity regulates progression through endoreduplication cycles; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity. | 0.905 |
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