STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BaccBacchus; Negatively regulates tyramine beta-hydroxylase tbh and thus the conversion of tyramine (TA) to octopamine (OA). In tyrosine decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling pathway to negatively regulate acute ethanol sensitivity probably via tbh-mediated depletion of TA. (152 aa)    
Predicted Functional Partners:
HmgZ
High mobility group protein Z; Transcription factor binding; DNA binding, bending.
   
    0.810
Tbh
Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family.
    
 
 0.616
bnb
Protein bangles and beads; May play an important role during development.
   
  
 0.556
NK7.1
NK7.1, isoform A; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; cell differentiation.
      
 0.543
CG31145
Extracellular serine/threonine protein CG31145; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.
      
 0.532
meng
Serine/threonine-protein kinase meng-po; Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM).
      
 0.497
alpha-Est10
Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
      
 0.493
jar
Myosin heavy chain 95F; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules and may be involved in transport in the early embryo and in the dynamic process of dorsal closure. It is believed that its function changes during the life cycle.
   
  
 0.455
HmgD
High mobility group protein D; Binds preferentially single-stranded DNA and unwinds double- stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1.
   
   0.447
CG6145
RH58004p; NAD+ kinase activity. It is involved in the biological process described with: NADP biosynthetic process.
      
 0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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