node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arr1 | Mppe | FBpp0298351 | FBpp0308658 | Phosrestin-2; Regulates photoreceptor cell deactivation. Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade. | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | 0.572 |
Arr1 | ninaE | FBpp0298351 | FBpp0083266 | Phosrestin-2; Regulates photoreceptor cell deactivation. Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.981 |
EMC3 | Mppe | FBpp0079711 | FBpp0308658 | ER Membrane protein Complex 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | 0.449 |
EMC3 | ninaE | FBpp0079711 | FBpp0083266 | ER Membrane protein Complex 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.533 |
Mppe | Arr1 | FBpp0308658 | FBpp0298351 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Phosrestin-2; Regulates photoreceptor cell deactivation. Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade. | 0.572 |
Mppe | EMC3 | FBpp0308658 | FBpp0079711 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | ER Membrane protein Complex 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. | 0.449 |
Mppe | PGAP3 | FBpp0308658 | FBpp0085453 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Post-GPI attachment to proteins 3 (PGAP3) encodes a protein involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation. Lipid remodeling consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchored proteins. The product of PGAP3 is required for the phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling. | 0.544 |
Mppe | Vha68-3 | FBpp0308658 | FBpp0080002 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Vacuolar H[+] ATPase 68kD subunit 3; ATP binding; proton-transporting ATPase activity, rotational mechanism. It is involved in the biological process described with: proton transmembrane transport; ATP metabolic process. | 0.494 |
Mppe | alpha-Man-IIa | FBpp0308658 | FBpp0306417 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). | 0.878 |
Mppe | alpha-Man-IIb | FBpp0308658 | FBpp0306660 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | alpha-Mannosidase class II b (alpha-Man-IIb) encodes a mannosidase involved in cellular encapsulation response and glycoprotein metabolism. | 0.505 |
Mppe | alpha-Man-Ia | FBpp0308658 | FBpp0288908 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Mannosyl-oligosaccharide alpha-1,2-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). | 0.474 |
Mppe | mRpL40 | FBpp0308658 | FBpp0081860 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Mitochondrial ribosomal protein L40; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation. | 0.602 |
Mppe | ninaA | FBpp0308658 | FBpp0077688 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. Belongs to the cyclophilin-type PPIase family. | 0.511 |
Mppe | ninaE | FBpp0308658 | FBpp0083266 | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization. | 0.685 |
PGAP3 | Mppe | FBpp0085453 | FBpp0308658 | Post-GPI attachment to proteins 3 (PGAP3) encodes a protein involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation. Lipid remodeling consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchored proteins. The product of PGAP3 is required for the phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling. | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | 0.544 |
Vha68-3 | Mppe | FBpp0080002 | FBpp0308658 | Vacuolar H[+] ATPase 68kD subunit 3; ATP binding; proton-transporting ATPase activity, rotational mechanism. It is involved in the biological process described with: proton transmembrane transport; ATP metabolic process. | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | 0.494 |
Vha68-3 | ninaA | FBpp0080002 | FBpp0077688 | Vacuolar H[+] ATPase 68kD subunit 3; ATP binding; proton-transporting ATPase activity, rotational mechanism. It is involved in the biological process described with: proton transmembrane transport; ATP metabolic process. | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. Belongs to the cyclophilin-type PPIase family. | 0.486 |
alpha-Man-IIa | Mppe | FBpp0306417 | FBpp0308658 | Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). | Metallophosphoesterase, isoform E; Metallophosphoesterase (Mppe) encodes a Mg[2+]- or Mn[2+]-dependent serine/threonine phosphatase. | 0.878 |
alpha-Man-IIa | alpha-Man-IIb | FBpp0306417 | FBpp0306660 | Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). | alpha-Mannosidase class II b (alpha-Man-IIb) encodes a mannosidase involved in cellular encapsulation response and glycoprotein metabolism. | 0.803 |
alpha-Man-IIa | alpha-Man-Ia | FBpp0306417 | FBpp0288908 | Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). | Mannosyl-oligosaccharide alpha-1,2-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). | 0.575 |