STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cactinCactin; Plays a role during early embryonic development. Involved in the dorsal-ventral embryonic patterning. Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway. Belongs to the CACTIN family. (720 aa)    
Predicted Functional Partners:
Pli
Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.
      
 0.799
Stoml2
Stomatin like 2, isoform A.
 
      0.768
cact
NF-kappa-B inhibitor cactus; Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation.
    
 
 0.724
ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Involved in the innate immune response. Promotes the production of antibacterial peptides; Belongs to the ECSIT family.
   
  
 0.611
Uba1
Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family.
 
 
    0.611
Deaf1
Deformed epidermal autoregulatory factor 1; Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd.
    
 
 0.584
rb
Ruby (rb) encodes the beta3-adaptin subunit of the Adaptor protein-3 (AP-3) complex involved in biogenesis of lysosome-related organelles. It is required for regulation of lipid storage, eye pigment biogenesis and the processing of the receptor encoded by N.
   
 
 0.555
CG15525
MIP04834p.
   
  
 0.509
CG8027
FI02838p; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. It is involved in the biological process described with: N-glycan processing to lysosome; carbohydrate phosphorylation.
   
  
 0.506
CG13465
Brother of Bearded protein A.
      
 0.461
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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