STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pp2C1Protein phosphatase 2C, isoform A; Cation binding; mitogen-activated protein kinase binding; magnesium-dependent protein serine/threonine phosphatase activity; oxidoreductase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: oxidation-reduction process; protein dephosphorylation. (1427 aa)    
Predicted Functional Partners:
CG1750
Uncharacterized protein; methionyl-tRNA formyltransferase activity. It is involved in the biological process described with: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; biosynthetic process.
  
   0.651
lok
Ovarian-specific serine/threonine-protein kinase Lok; May have a role in germline establishment.
    
 
 0.629
CG9784
Uncharacterized protein, isoform C; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. It is involved in the biological process described with: positive regulation of flagellated sperm motility; phosphatidylinositol dephosphorylation; inositol phosphate dephosphorylation.
   
  
 0.612
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
  
 
 0.594
tefu
Serine/threonine-protein kinase ATM; Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin- modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV. Belongs to the PI3/PI4-kinase family. AT [...]
      
 0.578
Pat1
Protein interacting with APP tail-1 (Pat1) encodes a protein required for the product of Khc to transport cargo and to maximize its motility. In oocytes the products of Pat1 and Klc act in a redundant manner.
   
 
 0.518
MED31
Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated t [...]
   
 
 0.506
5PtaseI
5PtaseI, isoform C; Inositol-polyphosphate 5-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; inositol phosphate-mediated signaling; phosphatidylinositol dephosphorylation.
   
  
 0.503
CG8878
BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation.
   
 
 0.502
MKP-4
Dual specificity protein phosphatase MPK-4; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response.
    
 
 0.498
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.