STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TpnC73FTroponin C, isoform 3; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (155 aa)    
Predicted Functional Partners:
Mlc1
Myosin light chain alkali; Microfilament motor activity; calcium ion binding. It is involved in the biological process described with: muscle contraction; mesoderm development.
  
  
 0.953
Mlc2
Myosin light chain 2 (Mlc2) encodes a subunit of the myosin complex involved in myofibril assembly. It contributes to different flight-related processes including wing beat frequency, and indirect flight muscle contraction.
  
 
 0.918
Mp20
Muscle-specific protein 20; It is involved in the biological process described with: myoblast fusion; regulation of myoblast fusion.
   
 
 0.899
Tm2
Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis.
   
 
 0.896
TpnC47D
Troponin C, isoform 2; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: microtubule cytoskeleton organization; calcium-mediated signaling.
  
  
0.843
wupA
Wings up A (wupA) encodes a cytoskeletal protein of the troponin complex of the muscle thin filament. It is involved in calcium-dependent regulation of muscle contraction, and in development of the embryonic heart, skeletal muscle and flight muscle It also contributes to non-muscle functions such as apico-basal polarity formation, nuclear division and maintenance of nuclear integrity.
   
 
 0.837
up
Troponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere.
   
 
 0.816
CG5177
Trehalose 6-phosphate phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
   
    0.750
Neurochondrin
Neurochondrin homolog; Strongly up-regulated in Mhc mutants suggesting a role in muscle function; Belongs to the neurochondrin family.
   
  
 0.731
Act57B
Actin-57B; Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle.
   
 
 0.708
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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