STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BiliBand4.1 inhibitor LRP interactor, isoform B; It is involved in the biological process described with: negative regulation of canonical Wnt signaling pathway. (828 aa)    
Predicted Functional Partners:
nkd
Protein naked cuticle; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification. Belongs to the NKD family.
   
  
 0.674
Ccm3
Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation.
    
 
 0.664
Sec22
Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family.
      
 0.538
CG5646
SD08189p; Acyl carnitine transmembrane transporter activity; transmembrane transporter activity. It is involved in the biological process described with: amino acid transport; acyl carnitine transport; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.497
rhea
Rhea, isoform B; Rhea (rhea) encodes fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing shg transcription in follicle cells.
    
 
0.482
CG5022
FI22325p1; Cytoskeletal protein binding. It is involved in the biological process described with: actomyosin structure organization.
   
  
 0.453
cora
Protein 4.1 homolog; An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development.
      
 0.420
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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