STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG12025RH22148p. (170 aa)    
Predicted Functional Partners:
CG32191
MIP05773p; Sulfuric ester hydrolase activity.
      
 0.931
Vps13
Vacuolar protein sorting-associated protein 13; Plays a role in the survival of neurons by maintaining protein homeostasis in the central nervous system. May function as part of a lysosomal degradation pathway.
      
 0.820
Ptp4E
Protein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr.
      
 0.732
Ptp10D
Protein tyrosine phosphatase 10D (Ptp10D) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp4E. Ptp4E-Ptp10D double mutants have lethal respiratory defects. Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp10D regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. It also binds to the product of sas to regulate its signaling in glia.
      
 0.714
ScsbetaG
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
      
 0.456
ninaE
Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization.
      
 0.424
mRpS2
Mitochondrial ribosomal protein S2; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
   
  
 0.422
CG44085
Uncharacterized protein, isoform O; MAP-kinase scaffold activity.
      
 0.422
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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