STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp6a14Probable cytochrome P450 6a14; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (509 aa)    
Predicted Functional Partners:
Cpr
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. In the N-terminal section; belongs to the flavodoxin family.
 
  
 
 0.618
shd
Ecdysone 20-monooxygenase; Shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation; Belongs to the cytochrome P450 family.
  
 
 0.583
Cyp303a1
Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.487
alpha-Est2
Alpha-Esterase-2, isoform A; Carboxylic ester hydrolase activity.
 
 
  
 0.465
alpha-Est5
Alpha-Esterase-5, isoform B; Carboxylic ester hydrolase activity.
 
 
  
 0.453
Cyp12a4
Probable cytochrome P450 12a4, mitochondrial; Has a role in resistance to insecticide lufenuron, but no other insecticides.
  
 
0.446
Hsp70Ba
Heat-shock-protein-70Ba (Hsp70Ba) encodes a protein involved in response to heat shock and hypoxia.
    
 
 0.442
Cyp305a1
Probable cytochrome P450 305a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.440
CG11899
Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
      
 0.433
CG1461
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
  
 0.431
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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