STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sphinx2Sphinx2, isoform B; Sphinx2 (sphinx2) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland. (253 aa)    
Predicted Functional Partners:
sphinx1
Sphinx1 (sphinx1) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland.
  
 
0.930
SPE
Spaetzle-processing enzyme heavy chain; Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections. Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection. Acts downstream of protease psh in response to fungal infection. Belongs to the peptidase S1 family. CLIP subfamily.
     
 0.918
grass
Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily.
     
  0.900
CG16790
U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
      
 0.834
sphe
Spheroide (sphe) encodes a serine protein homologue, a serine protease with no catalytic activity.
      
 0.798
Semp1
Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female.
   
  
 0.673
CG4815
IP10137p; Serine-type endopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; Belongs to the peptidase S1 family.
   
  
 0.613
psh
Serine protease persephone; Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases. Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz. Nec regulates the cascade by inhibiting psh ; Belongs to the peptidase S1 family. CLIP subfamily.
      
 0.600
intr
Intrepid; Serine-type endopeptidase activity. It is involved in the biological process described with: sperm storage; proteolysis; negative regulation of female receptivity, post-mating; multicellular organism reproduction.
   
  
 0.565
CG10587
Uncharacterized protein, isoform C; Serine-type endopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; Belongs to the peptidase S1 family.
   
  
 0.533
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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