STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thoc6THO complex subunit 6; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the WD repeat THOC6 family. (350 aa)    
Predicted Functional Partners:
thoc5
THO complex subunit 5; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC5 family.
   
 0.999
thoc7
THO complex protein 7; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC7 family.
   
 0.999
Hpr1
Hpr1 protein; It is involved in the biological process described with: mRNA export from nucleus in response to heat stress; mRNA export from nucleus; regulation of DNA-templated transcription, elongation; signal transduction.
   
 0.999
tex
Tex protein; It is involved in the biological process described with: mRNA export from nucleus.
   
 0.999
tho2
Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs.
    
 0.999
Hel25E
ATP-dependent RNA helicase WM6; Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin.
   
 0.971
Ref1
RNA and export factor binding protein 1; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.964
Flacc
Fl(2)d-associated complex component; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, acts as a key regulator of m6A methylation by bridging fl(2)d to the RNA-binding component nito. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines fem [...]
    
 
 0.856
Rae1
Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation.
   
  
 0.781
CG8149
LD31448p; It is involved in the biological process described with: wing disc dorsal/ventral pattern formation; larval lymph gland hemopoiesis.
   
 
 0.775
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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