STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG42685PLAT domain-containing protein. (1609 aa)    
Predicted Functional Partners:
JYalpha
Sodium/potassium-transporting ATPase subunit alpha; JYalpha (JYalpha) is a gene essential for male fertility as mutants produce immotile sperm.
   
 
 0.526
Pkd2
Polycystic kidney disease 2 (Pkd2) encodes a calcium permeable cation channel of the transient receptor potential (TRP) family. Its roles include sperm motility, smooth muscle contraction, larval feeding behavior, detection of mechanical stimuli and cold nociception.
   
 
 0.524
brv1
Brivido-1; Calcium channel activity; calcium ion binding. It is involved in the biological process described with: detection of temperature stimulus involved in thermoception; detection of mechanical stimulus; cellular response to cold; calcium ion transport.
   
 
 0.521
brv3
Brivido-3, isoform C; Calcium ion binding; calcium channel activity. It is involved in the biological process described with: calcium ion transport; detection of mechanical stimulus; response to cold.
   
 
 0.497
brv2
Brivido-2, isoform A; Calcium ion binding; calcium channel activity. It is involved in the biological process described with: detection of temperature stimulus involved in thermoception; detection of mechanical stimulus; cellular response to cold; calcium ion transport.
   
 
 0.496
Cadps
Calcium-dependent secretion activator; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. However, it probably also participates in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
      
 0.491
Ppr-Y
Protein phosphatase 1 regulatory subunit.
   
  
 0.478
CG9065
LP17418p; Copper chaperone activity. It is involved in the biological process described with: copper ion transport; respiratory chain complex IV assembly; mitochondrial cytochrome c oxidase assembly.
      
 0.459
CG6443
LD41227p; It is involved in the biological process described with: mitotic DNA replication termination; site-specific DNA replication termination at RTS1 barrier.
   
  
 0.430
ORY
Occludin-Related Y.
   
  
 0.420
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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