Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AWZ03_012348Uncharacterized protein. (1802 aa)    
Predicted Functional Partners:
AWZ03_007739
UMA domain-containing protein.
    
 0.944
AWZ03_011352
Uncharacterized protein.
    
 0.934
AWZ03_007527
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
   
 0.931
AWZ03_004946
Uncharacterized protein.
   
 0.918
AWZ03_004677
Uncharacterized protein.
   
 0.881
AWZ03_013493
Uncharacterized protein.
   
 0.828
AWZ03_004555
Uncharacterized protein; Belongs to the peptidase M16 family.
      
 0.802
AWZ03_001939
Receptor protein-tyrosine kinase.
    
 0.796
AWZ03_000503
Uncharacterized protein.
   
 0.793
AWZ03_001405
Arrestin_C domain-containing protein.
    
 
 0.773
Your Current Organism:
Drosophila navojoa
NCBI taxonomy Id: 7232
Other names: D. navojoa
Server load: low (6%) [HD]