STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
calypsoUbiquitin carboxyl-terminal hydrolase calypso; Polycomb group (PcG) protein. Catalytic component of the PR- DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys- 48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Belongs to the peptidase C12 family. BAP1 subfamily. (475 aa)    
Predicted Functional Partners:
DperGL11890
GL11890.
    
 0.994
DperGL26475
GL26475.
   
 0.970
DperGL18169
GL18169.
    
 0.969
DperGL11443
GL11443.
    
 0.961
DperGL11444
GL11444.
    
 0.961
DperGL22667
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 0.954
DperGL20068
GL20068.
   
 0.953
DperGL10628
GL10628.
   
 0.950
DperGL24166
GL24166; Belongs to the AAA ATPase family.
   
 0.949
DperGL13830
GL13830.
   
 0.946
Your Current Organism:
Drosophila persimilis
NCBI taxonomy Id: 7234
Other names: D. persimilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.