STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THOM_0187DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (848 aa)    
Predicted Functional Partners:
THOM_0241
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
 
 0.998
THOM_2797
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
   
 0.989
THOM_3040
Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4.
    
 0.983
THOM_1450
Endonuclease MUS81.
    
 0.971
THOM_1086
Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit.
    
 0.955
THOM_2061
DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.
  
 0.900
THOM_1138
Meiotic recombination protein Dmc1; Belongs to the RecA family.
  
 0.861
THOM_2808
5'-3' exonuclease.
  
 0.837
THOM_2066
DNA replication helicase.
    
 0.832
THOM_2540
DNA repair and recombination protein RAD52/RAD22.
    
 0.823
Your Current Organism:
Trachipleistophora hominis
NCBI taxonomy Id: 72359
Other names: T. hominis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.