node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DsecGM12567 | DsecGM16420 | B4I086 | B4IJ27 | GM12567. | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | 0.741 |
DsecGM12567 | DsecGM16519 | B4I086 | B4II06 | GM12567. | GM16519. | 0.852 |
DsecGM12567 | DsecGM26397 | B4I086 | B4HM85 | GM12567. | GM26397; Belongs to the DEAD box helicase family. | 0.549 |
DsecGM12567 | GM12330 | B4I086 | B4HW93 | GM12567. | Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. | 0.956 |
DsecGM14463 | DsecGM16420 | B4HW36 | B4IJ27 | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | 0.882 |
DsecGM16420 | DsecGM12567 | B4IJ27 | B4I086 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | GM12567. | 0.741 |
DsecGM16420 | DsecGM14463 | B4IJ27 | B4HW36 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.882 |
DsecGM16420 | DsecGM16519 | B4IJ27 | B4II06 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | GM16519. | 0.810 |
DsecGM16420 | DsecGM18297 | B4IJ27 | B4I2C2 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | Eukaryotic translation initiation factor 5A. | 0.990 |
DsecGM16420 | DsecGM20962 | B4IJ27 | B4HR34 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.731 |
DsecGM16420 | DsecGM25027 | B4IJ27 | B4HJE2 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | GM25027. | 0.989 |
DsecGM16420 | DsecGM26397 | B4IJ27 | B4HM85 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | GM26397; Belongs to the DEAD box helicase family. | 0.777 |
DsecGM16420 | DsecGM26640 | B4IJ27 | B4HHN0 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | GM26640. | 0.889 |
DsecGM16420 | GM12330 | B4IJ27 | B4HW93 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. | 0.736 |
DsecGM16420 | GM23154 | B4IJ27 | B4II68 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. | 0.891 |
DsecGM16519 | DsecGM12567 | B4II06 | B4I086 | GM16519. | GM12567. | 0.852 |
DsecGM16519 | DsecGM16420 | B4II06 | B4IJ27 | GM16519. | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | 0.810 |
DsecGM16519 | DsecGM26397 | B4II06 | B4HM85 | GM16519. | GM26397; Belongs to the DEAD box helicase family. | 0.909 |
DsecGM16519 | GM12330 | B4II06 | B4HW93 | GM16519. | Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. | 0.881 |
DsecGM18297 | DsecGM16420 | B4I2C2 | B4IJ27 | Eukaryotic translation initiation factor 5A. | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A- mediated translational control. | 0.990 |